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We are all one human race on one small planet, and we are manipulated and controlled by a comparatively tiny group of men who are squeezing every bit of profit out of our ever decreasing resources. ![]() Waters left Floyd partly because he wanted to continue emphasizing his antiwar message in his work, and I thank him for that, because his message speaks to me. She had a point in that Floyd was mind blowing for people using hallucinogens etc, but. I saw him many years ago with my brother and his wife's comment was "that's druggie music". The music has aged with me, and become more meaningful as I've grown more knowledgeable of world history, and especially the 20th century. I introduced RW's solo albums to my wife 20 years ago and we both consider Amused to Death one of our absolute favorite albums. I'm 44 now and the music hasn't gotten old. I have been listening to PF since I was ten. Projection screens! I don't want to give any Rigging, starts lowering over the audience'sīecome a series off giant, and I mean giant, Gosh! I can't even explain! This contraption, Theshow! but after the intermission, oh my Learning they never got the tape beforehandĪnd learned the whole routine right before The children who performed during Brick in Spectacular as far as the set, or any surprised. The show was mostly Pink Floyd, with a few Well he sounds exactly the same as always. Hyped if as the best show EVER, I was notĭisappointed.
The owners of the 2 biggest mobile phone platforms in the world team up to make an interoperable system that would allow Bluetooth-enabled tracing work seamlessly between Android and iOS devices – and maybe, even between different contact tracing apps. ABS-CBN reported that the company is also working on ways for people to “check in” their information without a smartphone or internet access.Īpple and Google-made project. Local government can only see the data in their specific city or municipality.ĬovCT – A platform developed by Singapore-based Madison Technologies, first available in Malaysia in April, and now in the Philippines. Local government can register on the site to see the aggregated data on virus spread, and not individual data. It’s a self-reporting tool found on the FASSSTER website. This is the contact tracing feature of forecasting tool FASSSTER (Feasibility Analysis of Syndromic Surveillance using Spatio-Temporal Epidemiological Modeler). The developers said that the usage patterns in the Philippines has been considered such as the dominance of prepaid use and levels of internet penetration. ![]() The platform uses Huawei Cloud as its cloud infrastructure, and has partnerships with Globe and PLDT, which will provide subscribers access to the app. Developed by students from the Master of Science in Innovation and Business graduate degree program at the Asian Institute of Management.ĬLEAR (Citizen’s Logistics and Early Assessment Report Tool) – Developed by Philippine firms Spring Valley Tech Corp (owned by the president of the Philippine Software Industry Association), and CMI Tech. Developed by a Cebuano scholar of the Department of Science and Technology.ĮNDCoV. A contact tracing app in Cebu, which Governor Gwendolyn Garcia has required for everyone in the province to install. Will generate a heat map for infections using self-reported information. Government app and website developed and managed for free by PLDT-backed Multisys Technologies Corporation. In the Philippines, here are the apps and online platforms trying to do that now: The rise of these apps has also triggered a response from privacy advocates and experts, calling for strict guidelines on maintaining private information secure, anonymous, and protected from potential abuse by the state and other parties.įrance, Israel, Germany, Singapore, South Korea, and other Asian countries have deployed or have made proposals for similar tech-assisted contact tracing measures along with other quarantine monitoring methods. With the information, people can take measures to protect themselves and others.ĭesign and the technology used may vary among apps and platforms but the core service is the same: monitor where the virus is spreading, and alert people immediately if they are in danger of having been infected and infecting others. 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In 1926, the Cleansweep Broom Company was founded, and the first racing broom was invented. ![]() ![]() Despite broomstick riding becoming a nearly universal method of travel, it was still the case that brooms were made by craftsmen on an individual basis. In 1820, Elliot Smethwyck invented the Cushioning Charm, which became a necessity for broomstick riding. It would take another 700 years before brooms would reach the level of quality and efficiency allowing them to be used for racing, though some Wizards did try over the years. By the late 12th Century, broom-making had become a sought-after skill, and many Wizards decided to turn this into a trade. As time went on, and broomstick magic became mainstream, Wizarding families would begin to construct their own brooms that better suited the user. To make matters worse, the charms that Wizards and Witches were using on brooms at the time were also incredibly simple, not allowing for smooth movement once in the air. ![]() In 1107, Scottish Wizard Guthrie Lochrin once again described the discomfort of riding a broom, even for a short duration, proving that no technological advancements had taken place. These descriptions make it clear that prototype brooms were not comfortable use, nor were they particularly effective, having little to no aerodynamic qualities. The everyday broomstick was the ideal choice, being easily portable and cheap.Įuropean Witches were the first in the Wizarding society to use brooms as vehicles for flight, with detailed descriptions of the experience dating all the way back to the year 962. To remain hidden from the human population, Wizards and Witches decided that everyday objects were the perfect item to charm, blending in naturally within a household setting. The Wizarding World instead turned its attention to charming objects in order to achieve flight. The closest the Wizarding World ever gets to flying is with its Animagi population, who are able to transform into animals at will. RELATED: Hogwarts Legacy Shouldn't Ignore Hufflepuff and Ravenclaw Like the Movies Do The History of Broomstick Magicĭespite having the ability to transfigure inanimate objects into living beings, grow plants in a matter of seconds, and even stop someone's heart, the Wizarding World has never included a spell that allows people to fly on their own. As with all things in the Harry Potter universe, there's a rich history of lore behind these Broomstick Races. While players may not to use their broom in a game of Quidditch, they will be able to take to the skies and participate in Broom Races, as well as use them to traverse the open-world. That being said, based on the few Hogwarts Legacy trailers released so far, it does seem the game is shaping up nicely, bringing a variety of mechanics that seek to capture the magic of the Wizarding World.Īlong with a range of destructive and defensive spells, creating a sanctuary in the Room of Requirement, and facing off against some of the series' iconic magical beasts, Hogwarts Legacy will also allow players to ride on their own broomstick. Fans are sure to see a slew of new trailers over the next few months, showing more plot details and gameplay. With a 2022 release date in place, fans will finally get to play the long-awaited Hogwarts Legacy this year. ![]() There are a few bloody scenes, but thanks to the MPA, the goriness was left on the cutting room floor. Sadly, the ones in Spiral are a disappointment. The not-so-good Saw entries had at least creative death traps and gore. Instead, it's a pointless sequel that adds nothing new to the series. I, for one, was hoping Spiral: From the Book of Saw would rejuvenate the franchise, but sadly that's not the case. ![]() The Consequences of Your Actions: Creating Spiralĭrawing Inspirations: Illustrated Trap Breakdowns It only made $37.5 million at the box office against a $20 million budget.Īudio Commentary with Director Darren Lynn Bousman, Co-Screenwriter Josh Stolberg, and Composer Charlie ClouserĪudio Commentary with Producers Oren Koules and Mark Burg The film received mixed to negative reviews from critics and filmgoers. Why? The only theater in my area is currently closed. Despite my love for the Saw franchise, I didn't attempt to see the movie in theaters. ![]() I was skeptical when I first heard that Chris Rock would produce and star in the spinoff Spiral: From the Book of Saw. Sure, he's good at comedy, but I had my doubts he could carry a horror film.Īfter being delayed for almost a year, Lionsgate released Spiral: From the Book of Saw to theaters on May 21, 2021. (Yes, I know I'm old.) While there have been a few half-ass sequels ( Saw V and Saw 3D), I've continued to watch each new film, even 2007's reboot sequel Jigsaw. I've been a fan of these films ever since I rented Saw on VHS in early 2005. The Sawfilm series is one of the slickest and sickest horror franchises in recent years. It's also available on Digital and Demand. With the new release date just a few months away, we expect a second one to drop soon.Yesterday, Lionsgate Home Entertainment released Spiral: From the Book of Saw (R 93 minutes) on 4K Ultra HD Combo Pack, Blu-ray Combo Pack, and DVD. You can watch the first trailer right here. If the health crisis continues to mess with theaters by the time the spring rolls around, there's a decent chance the reboot will be delayed again or possibly shifted to a streaming service. It was originally supposed to open last May, but was delayed to this year as a direct result of the COVID-19 pandemic. Spiral is set to hit theaters Friday, May 21. I felt like I could have stepped outside and the movies still would have continued. Jackson ( Marvel's Secret Invasion) plays Zeke's father, Marcus Banks. Marisol Nichols ( Riverdale) and Zoie Palmer ( Dark Matter) round out the rest of the principal cast.īousman also explained why he exited the franchise in the first place, stating that it had become "such a well-oiled machined. He plays Detective Zeke Banks, a New York City homicide cop who starts investigating a string of grisly killings throughout the Big Apple, which are somehow connected to the infamous Jigsaw killer. Max Minghella ( The Handmaid's Tale) takes on the role of Zeke's young partner, Detective William Schenk, while Samuel L. Not content to stay behind-the-scenes, Rock is also Spiral's leading man. He would make these obscure references and I'd be like, 'How the f*** do you know that?'" "He's not only got the genre, he was kind of an expert in it. This is much more about character, tension, and fear."īeing a comedian by trade, though, Rock helped infuse the screenplay (written by series veterans Josh Stolberg and Peter Goldfinger) with some "outrageously hilarious" elements that helps offset the film's more nihilistic elements. Gore and violence is no longer a gimmick - it just serves the story. Gore and violence was the gimmick, I think. We wanted it to feel much more like Se7en, but it has so many ties to the mythos of Saw . ![]() He pitched this very elaborate, dense idea," director Darren Lynn Bousman, who previously helmed Saws II - IV, told Empire Magazine for the publication's March 2021 issue. That idea eventually became Spiral: From the Book of Saw, which hopes to reboot the franchise with a dark and gritty take that steers clear of the torture porn formula. What's in the box?! Chris Rock wasn't playing any Jigsaw-type games when he approached the head of Lionsgate at a friend's wedding and pitched them a brand-new project set within the Saw universe. E-Sword - the world's most popular PC Bible study software is now available on the world's most advanced desktop operating system! E-Sword X is a complete re-design of the PC version of e-Sword, capitalizing on what we have learned from 15 years of writing Bible software. The all-in-one tool to move a Final Cut Pro X Event or Project to Premiere Pro, After Effects, Audition, FCP 7 and beyond! This app translates Final Cut Pro X Library XML (fcpxml) and converts it for import into Adobe's Creative Cloud apps, Premiere Pro CS6, Final Cut Pro 6 or 7, or other applicati. Dado que Adobe Stock solo garantiza el derecho de uso de las imágenes y no otorga ningún tipo de titularidad, dichas imágenes no se pueden utilizar como logotipo ni como parte del mismo. 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This time you will have to master other tools as well if you want to complete the ultimate challenges, tools such as the heater, A/C, a global music box, a power generator, and more. Mix and match any assortment of characters that you like, set their difficulty from 0-20, then jump right into the action! From your office desk, you will need to manage two side doors, two vents, as well as two air hoses, all of which lead directly into your office. Welcome to the ultimate FNAF mashup, where you will once again be trapped alone in an office fending off killer animatronics! Featuring 50 selectable animatronic characters spanning seven Five Nights at Freddy's games, the options for customization are nearly endless. It is also confirmed by Scott on a recent Steam Post that this would currently be his last Five Nights at Freddy's game.īesides introducing over 50 animatronic characters, the Ultimate Custom Night includes special features, such as the challenge menu with 16 themed challenges, voice acting, unlockable office skins, and unlockable cutscenes. He had also announced that Custom Night will be released as a standalone game instead of an update for Freddy Fazbear's Pizzeria Simulator for the sake of launching and playing more easily. He had completed all of the characters and had released a demo of the game for a few YouTubers to play, along with voice acting auditions for nearly every character present on the roster. ![]() Scott Cawthon had offered some information about the characters' behavior as he slowly added each member of the roster into the game. All characters are known to have customizable AI, except for characters summoned by Dee Dee and XOR ( RWQFSFASXC, Plushtrap, Nightmare Chica, Bonnet, Lolbit, Minireena) and Fredbear. Īs a first in the series, Ultimate Custom Night seems to include a variety of animatronics from all preceding games, from the first to sixth installment, while other characters are introduced ( Dee Dee and Old Man Consequences from FNaF World). It was released on June 27, 2018, on Steam, with a mobile port releasing for iOS and Android on April 28, 2020, and console ports releasing just over a year later on April 30th, 2021. As requested by the community and described by Scott as an "Ultimate Custom Night", the game features fifty-nine antagonists in total, making this the biggest variation of the mode in any game yet. ![]() Ultimate Custom Night, or UCN for short, is the seventh Five Nights at Freddy's installment that is published by ScottGames as well as the final game of the series to customize the animatronics' A.I.s. Steam description, Ultimate Custom Night “ Welcome to the ultimate FNAF mashup, featuring 50 selectable characters and custom difficulties! ” ![]() ![]() Want to get support and share your feedback on using Dropbox for macOS? Join the conversation in our community forum. 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Here are few ways you can fix Dropbox not syncing issues for Windows 10/ 7 and macOS.We’re working directly with a small subset of macOS users with complex configurations to ensure their migration is as seamless as possible. If you’re not seeing the Dropbox badge, please check to ensure the following: You have the Dropbox desktop application installed on your computer ( currently our latest stable version is 53.4.If you haven’t already received the new Dropbox for macOS with support for the File Provider API, you can expect it between now and the end of May 2023. This updated experience is more deeply integrated with macOS and comes with some changes required by the API.ĭropbox is actively working to preserve the reliability and quality of our sync experience along with these changes. The latest version of Dropbox for macOS utilizes Apple’s updated File Provider API and fixes issues related to opening online-only files in third-party applications. 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Super-enhancers (SEs) are clusters of enhancers that are occupied by exceptionally high densities of interacting factors, including TFs, co-factors (e.g., p300, BRD4, and MED1), RNA polymerase II, and non-coding RNAs 23. This could be highly desirable for some biological processes, such as the direct conversion of cell types and industrial applications 17, 18.Įnhancers are cis-regulatory elements (small segments of DNA) bound by TFs and other components of the transcription apparatus that modulate the expression of cell identity genes 19, 20, 21, 22. Thus, a new gene activation strategy based on this principle may effectively activate genes that are inaccessible to current CRISPRa methods. However, the use of multiple sgRNAs tiled across the target gene promoter can significantly improve CRISPRa efficiency, suggesting that recruiting as many TFs as possible may be crucial for activating gene expression with wider dynamic ranges 9, 10, 11, 16. ![]() The ability of CRISPRa to activate target genes by using single sgRNAs enables genome-wide transcriptional activation screens 14, 15. Based on this principle, the recently developed DNA-targeting platform, CRISPR-Cas9, has enabled the recruitment of artificial transcription factors (aTFs) to any specific genomic site to induce endogenous gene activation, termed CRISPR activation (CRISPRa) 9, 10, 11, 12, 13. TFs typically consist of two subdomains, a DNA-binding domain (DBD) and an activation domain (AD) which interacts with coactivator complexes to modulate transcriptional level 6, 7, 8. Transcription factors (TFs) ensure this specificity by recognizing and binding to specific DNA sequences to modulate gene expression through their effector domains 4, 5. Regulation of gene expression requires that the transcriptional machinery be precisely and efficiently assembled at specific genomic loci 1, 2, 3. Overall, our work expands the gene activation toolbox for biomedical research. Quantitative imaging illustrated that nascent RNA-directed aTFs could induce the high-density assembly of coactivators at transcription sites, which may explain the larger transcriptional burst size induced by Narta. Moreover, Narta provides better activation potency of some expressed genes than CRISPRa and, when used in combination with CRISPRa, has an enhancing effect on gene activation. Importantly, the activation is reversible, tunable and specific. Using Narta, we demonstrate robust activation of a broad range of exogenous and endogenous genes in various cell types, including zebrafish embryos, mouse and human cells. In contrast to existing methods based on recruiting transcriptional modulators via DNA-binding proteins, we developed a strategy termed Narta ( nascent RNA-guided transcriptional activation) to achieve gene activation by recruiting artificial transcription factors (aTFs) to transcription sites through nascent RNAs of the target gene. Technologies for gene activation are valuable tools for the study of gene functions and have a wide range of potential applications in bioengineering and medicine. |
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